Inconvenience of Convenience Cohorts—Letter

Inconvenience of convenience cohorts--letter.

The authors describe systematic sampling bias from socalled "convenience cohorts" in a review of studies addressing the prognostic significance of the PAX– FOXO1 fusion genes in rhabdomyosarcoma (1). They cite evidence that in at least two studies, samples for which fusion gene status was not determined had a different overall survival than those for which fusion status was determined. They pos...

The inconvenience of convenience cohorts: rhabdomyosarcoma and the PAX-FOXO1 biomarker.

"Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rh...

The convenience of tilings

Tiling problems provide for a very simple and transparent mechanism for encod ing machine computations This gives rise to rather simple master reductions showing various versions of the tiling problem complete for various complexity classes We in vestigate the potential for using these tiling problems in subsequent reductions showing hardness of the combinatorial problems that really matter We ...

Convenience Sampling

Convenience Sampling